Clinical trials for osteoarthritis of the knee. Osteoarthritis of the Knee - Scottsdale AZ.
Clinical trials for osteoarthritis of the knee Objective: To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA). BMAC provides a rich source of mesenchymal stem cells (MSCs) and is a … The "Osteoarthritis Initiative (OAI): A Knee Health Study" is a nationwide research study that will help researchers gather more information about the physical changes that occur prior to the onset of arthritis symptoms or before OA gets worse. Rofecoxib Phase III Protocol 035 Study Group, Rofecoxib, a specific inhibitor of cyclo-oxygenase 2, with clinical efficacy comparable with that of diclofenac sodium: results of a one-year, randomized, clinical trial in patients with osteoarthritis of the knee and hip. These regenerative therapies one day may offer alternatives to joint replacement. 24, 2025 (GLOBE NEWSWIRE) -- Enlivex Therapeutics Ltd. An unprecedented trial will study patients at risk of post-traumatic osteoarthritis in the knee, or knee PTOA, and involve scientists at nine world-class institutions. Mar 1, 2025 · We enrolled randomized controlled trials (RCTs) that compared the clinical efficiency of different doses of PRP injection in patients with knee osteoarthritis. MOVE study aims to investigate the effectiveness of the investigational medication, VENT-02, compared to placebo, to determine if the medication can help relieve knee osteoarthritis (OA) pain. Researchers from Tufts MC's Division of Rheumatology have been national leaders in the development of guidelines for treatment of knee osteoarthritis, in developing innovative ways to measure and assess damage to the knee, and in evaluating methods to treat osteoarthritis. The aim of our study was to investigate the effects of oral high-dose CBD administered over 8 weeks on pain Feb 22, 2022 · Background The Osteoarthritis Research Society International (OARSI) updated their guideline for clinical trials on knee osteoarthritis (KOA) in 2015, which contains recommendations for the conduct, design, and reporting of clinical trials. RTM is a statistical phenomenon that Apr 8, 2020 · Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Method This parallel, three-arm randomized controlled trial, conducted between 2022 and 2023, included 59 knee osteoarthritis (KOA) patients randomly allocated Dec 13, 2022 · Research on this condition will be crucial to improve the quality of life for those who are living with the condition. Data from previously conducted placebo-controlled clinical trials were normalized and collated. This randomized, double-blind, parallel-group clinical trial aims to assess the equivalence of intra-articular polynucleotides compared to standard hyaluronic acid (HA) viscosupplementation in the treatment of knee osteoarthritis (OA). On the other hand, all Clinical and cost-effectiveness of bracing in symptomatic knee osteoarthritis management: protocol for a multicentre, primary care, randomised, parallel-group, superiority trial Jun 3, 2022 · A randomised, controlled, double-blind, single-centre clinical trial was designed, in which three groups were assigned to different doses of an internal membrane, eggshell-based supplement (Figure 1). Methods We conducted a randomized placebo-controlled trial involving 110 patients with KOA who met the inclusion criteria. Osteoarthritis, Knee clinical trial. Therefore, the . In more advanced cases, that shot might also deliver a biomaterial repair Clinical trials & studies for OsteoarthritisIn recent years, the incidence rate and disability rate of osteoarthritis have continued to grow, and it has become a common chronic disease of elderly patients, second only to the "three highs", and poses a continuous threat to China's medical and health system and public health system. Methods Four databases were systematically searched (before August 1, 2024) to include randomized controlled trials (RCTs) of MSCs for OA. Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. Feb 3, 2025 · The trial is designed to assess the dose effect of iPPS for knee OA pain. Explore our active clinical trials to find opportunities to contribute to advancements in treatment, prevention, and care. Pain from arthritis is often due to underlying inflammation in the joint. Together, we can make a difference. Knee osteoarthritis is the main type of osteoarthritis, ranking Conclusion: This large, controlled randomized clinical trial confirms that 5 weekly IA injections of HA (Hyalgan) in patients with OA of the knee are generally well tolerated, provide sustained relief of pain and improved patient function, and were at least as effective with fewer adverse reactions as continuous treatment with naproxen for 26 weeks. An artificial knee joint has metal alloy caps for your thighbone and shinbone and high-density plastic to replace damaged cartilage. 2. Clinical trials & studies for Osteoarthritis, KneeToday, osteoarthritis (OA) is considered a whole-organ disease that is amenable to prevention and treatment in the early stages. There are currently no effective disease-modifying anti-rheumatic drugs licensed for the treatment of OA. Our latest clinical […] Apr 21, 2023 · In clinical trials and observational data for osteoarthritis, contextual factors are important to consider in relation to pain outcomes. Figure 1. Apr 21, 2022 · Background: Knee osteoarthritis (KOA) can cause chronic pain and seriously affect the quality of patient lives. Primary objectives were safety and efficacy according to a compound responder analysis of minimal clinically important difference in pain Nov 1, 2024 · This "Year in Review" presents a curated selection of research themes and individual studies within the clinical osteoarthritis (OA) field, focusing o… The goal of this clinical trial is to examine the effect of a single autologous, intra-articular injection of MFat versus corticosteroid injection for the treatment of pain and function associated with K/L grade 2/3 knee Osteoarthritis. If they are eligible for the study we shall provide them information about the clinical trial with the "Patient Information Sheet, quoting them for the Inclusion Visit. An initial review of the COMET database of core outcome sets (COS) was undertaken to identify all domains reported in previous COS including individuals with hip and/or knee OA. 4 million people in the UK, and 364 million globally. Explore and find osteoarthritis clinical trials and access the latest research and treatment options. Cannabidiol, which preclinically showed anti-inflammatory, analgesic activity, could supplement established analgesics, but robust clinical trials are lacking. This study is seeking participants with knee pain caused by primary OA or “wear-and-tear” OA. Jun 18, 2025 · Objective To assess and compare the clinical efficacy of various therapeutic options in treating patients with knee osteoarthritis (KOA). At the first inkling of a creaky knee, patients could get a single shot in the joint that would not only stop their cartilage and bone from eroding, but kick start its regrowth. Evans is hopeful that successful completion of the phase 1b trial in the second quarter of 2025 and subsequent larger trials will push the team closer to seeing scAAV. Accept or Reject optional Methods: A methodology was developed by an interaction of the Osteoarthritis Research Society International Standing Committee on Clinical Trials, biostatisticians, pharmaceutical company representatives and health agency representatives. May 20, 2020 · This review will select key OA pheno-endotypes according to relevant literature and current clinical trials/therapies that have been the most promising targets for recent clinical or pre-clinical studies. Mar 22, 2023 · This year, the team will launch a combined safety and preliminary efficacy clinical trial (Phases 1 and 2A) of R805/CX-011 for the treatment of osteoarthritis in patients in collaboration with the start-up Carthronix. Mar 11, 2025 · Therefore, the study team proposes the BEAR-MOON (Bridge-Enhanced ACL Repair) multi-center randomized non-inferiority clinical trial for co-primary outcomes AP (anterior-posterior) knee laxity and International Knee Documentation Committee (IKDC) validated patient reported outcome measure. Biologics are increasingly used for cartilage repair and osteoarthritis (OA) treatment. The guidelines were restricted to cover all currently available treatments for knee Jul 11, 2002 · Many patients report symptomatic relief after undergoing arthroscopy of the knee for osteoarthritis, but it is unclear how the procedure achieves this result. Paradigm Biopharmaceuticals has selected Advanced Clinical as the clinical research organisation (CRO) to support its pivotal double-blind, multi-centre Phase III trial, PARA_OA_012, focused on treating osteoarthritis (OA). Clinical trial coordinator Lindley Mattiazzi said the trial sought to assess the safety of an investigational treatment for knee pain due to osteoarthritis. varied comparators) in persons Cannon GWCaldwell JRHolt P et al. Nov 20, 2023 · Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. We also conducted general searches for manuscripts covering general imaging and randomized control trial (RCT) methods, covering each of the Jan 15, 2015 · It will recruit 12 patients with osteoarthritis of II-IV Kellgren and Lawrence grades, Patients will be evaluated clinically by previous studies imaging (X-rays and MRI). This meta-analysis is expected to provide evidence of the efficacy of stem cell therapy, which is currently controversial, Become part of research dedicated to improving the lives of people with osteoarthritis. Dec 20, 2016 · Background Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Methods The in vitro differentiation potential of adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (Stempeucel®) was determined by This randomized trial compares the effects of intra-articular triamcinolone vs saline injected every 3 months for 2 years on changes in cartilage volume and pain in older adult patients with knee osteoarthritis. The main question it aims to answer is: - How many study participants will experience side effects related Apr 19, 2024 · This randomized clinical trial evaluates the effectiveness of self-administered acupressure on reducing knee osteoarthritis (OA) pain among middle-aged and older adults. 40 participants with moderate knee osteoarthritis were randomised to receive a single intra-articular injection of MAG200 (dose cohorts:10, 20, 50, 100 × 10 6 cells) or placebo. Clinical trials are also performed to find more effective ways to prevent and diagnose this Oct 29, 2025 · The purpose of this clinical trial is to determine whether genicular artery embolization (GAE) is an effective way to treat knee pain from osteoarthritis. 12-15 A systematic review of randomized trials of land-based therapeutic exercise (vs. Whether the short-term and long-term ef Keywords: clinical trials, osteoarthritis, mesenchymal stem cells, intra-articular injection, cartilage regeneration 1. Mar 7, 2025 · Background The aim of this meta-analysis was to investigate the efficacy and safety of intra-articular injection of mesenchymal stem cells (MSCs) alone for the treatment of unoperated knee osteoarthritis (OA). The aim of this review is to provide an in-depth evaluation of the current treatment strategies for knee osteoarthritis (OA), focusing on their comparative efficacy, safety profiles, and practical applicability in clinical settings. Join now! The purpose of this study is to assess the safety, drug levels and effects on the body of MEDI7352, in participants with painful osteoarthritis of the knee. The continued emergence of high-quality RCTS requires us to update the quality of evidence. Feb 12, 2025 · Knee osteoarthritis (OA) isn’t just a condition—it can be a daily challenge for around 4 million people in the UK who experience chronic pain and reduced mobility due to OA[i]. Mar 5, 2024 · A new study at Duke, published in Nature, finds that mesenchymal stem cells (MSCs) offered the same level of benefit as injected corticosteroids to patients with knee osteoarthritis (OA). Feb 23, 2021 · This randomized clinical trail examines the effectiveness of internet-based exercises aimed at treating knee osteoarthritis (iBEAT-OA) vs usual care for pain in patients with knee osteoarthritis. Feb 6, 2025 · After years of work to overcome challenges, Dr. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. May 1, 2015 · This paper is the work of a large multidisciplinary group who were invited to participate in the Osteoarthritis Research Society (OARSI) Clinical Trials Imaging Working Group. Exploratory analyses suggest that the Sep 12, 2024 · Key Points 1. Clinical Trials on Osteoarthritis of the Knee in United Kingdom Total 4874 results ‹ 1 2 3 4 5 6 7 8 9 10 97 98 › AstraZeneca Completed Evaluate Safety, Tolerability, Pharmacokinetics and Immunogenicity of MEDI7352 in Healthy Volunteers Jan 23, 2024 · A single-centre, double-blind, ascending dose, randomised controlled trial. Jul 24, 2025 · Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis (ONWARDS) ClinicalTrials. “Volunteer for research and contribute to discoveries that may improve health care for you, your family, and your community!” open to eligible people ages 40-90 Lilly and our partners use optional cookies for analytics, personalization, and marketing. The study included a preclinical model and a phase I clinical trial study with 3 Cellistem doses. View more about this trial in ClinicalTrials. Participating in one of our studies can help to advance medicine and improve the lives of those with knee OA. Clinical trial for Development, Piloting and Evaluation of an Evidence-based Informed Consent Form for Total Knee Arthroplasty. CASCADE-OA study CASCADE-OA is a study looking at whether a self-guided physical activity program, designed for people with hip or knee Aug 28, 2024 · Trial participants would be asked to attend eight visits at the UniSC clinical trials Birtinya clinic on the Sunshine Coast, over a seven-month period. These May 14, 2025 · Participants were evaluated for clinical signs of inflammation at baseline, and then at 2 weeks, 2 months, and 6 months post-injection using clinical assessments, the Visual Analogue Scale (VAS), Knee injury and Osteoarthritis Outcome Score (KOOS), range of motion (ROM), and Magnetic Resonance Arthrography (MRA). Introduction Osteoarthritis (OA) is a disease that affects the integrity of diarthrodial joint tissues and is primarily characterized by the deterioration of hyaline cartilage [1, 2]. 3 However, investigators often overlook improvement that might be explained by regression to the mean (RTM). The Kellgren-Lawrence score is the most popular and has been used for over 40 years also in clinical trials. knee osteoarthritis (Section V, Clinical Endpoints Review). Aug 12, 2024 · MRI is a relatively new imaging modality in the setting of knee osteoarthritis clinical trials, but with exquisite soft tissue contrast and the ability to directly visualize early chondral abnormalities and whole organ disease, it is eclipsing radiography in importance. Apr 8, 2022 · Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices. About Osteoarthritis Research Osteoarthritis of the knee is a common joint condition that causes pain, stiffness, and reduced mobility. Published in Apr 8, 2025 · One of the most common reasons for knee replacement surgery is severe pain from joint damage caused by osteoarthritis. Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. Jul 29, 2024 · A single injection of a new, off-the-shelf stem cell therapy for knee osteoarthritis significantly improved pain and function for up to 12 months in 75% of participants involved in a clinical Jun 9, 2023 · A randomized double-blind clinical trial on the treatment of knee osteoarthritis: The efficacy of polynucleotides compared to standard hyaluronian viscosupplementation. Helping Daytona Beach patients explore new treatments for osteoarthritis of the knee through safe, expertly managed clinical studies. This randomized trial assesses the effect of injections of platelet-rich plasma vs saline placebo on 12-month changes in knee pain scores and medial tibial cartilage volume among patients with symptomatic mild to moderate knee osteoarthritis. Treatments targeting articular cartilage OA is characterized by the degradation of articular cartilage and bone matrix components. Interested in participating in arthritis clinical trials? Learn what to expect from a clinical trial and how you can get involved. Apr 2, 2025 · Several more large clinical trials are currently underway, and should increase our understanding of whether stem cell injections are safe and effective for knee osteoarthritis. We conducted a randomized, placebo-con Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial. To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA). Fifty men and women, 40e76 years of age with knee OA pain were enrolled in an outpatient medical center. Intervention was MSM 3 g or placebo twice a day for 12 weeks (6 g/day total). The outcomes were reduction in the Visual Analogue Scale (VAS) pain score or improvement of the total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. By participating in a clinical trial, which is strictly voluntary, a patient may help researchers discover a new life-saving medication or surgical procedure. The 5 days ago · New research from a randomized clinical trial provides the strongest long-term evidence yet comparing partial (PKR) and total (TKR) knee replacements for patients with osteoarthritis. The goal of this document is to update the original recommendations specifically for the design, conduct, and reporting of clinical trials that target symptom or structure modification among individuals with knee Nov 28, 2023 · To evaluate the efficacy and safety of intra-articular injection of mesenchymal stem cells (MSCs) versus hyaluronic acid (HA) in the treatment of knee osteoarthritis (KOA). Oct 29, 2020 · In this Review, the authors describe the pathophysiological targets and clinical effects of new drugs currently being investigated for the treatment of osteoarthritis. Apr 19, 2024 · This randomized clinical trial evaluates the effectiveness of self-administered acupressure on reducing knee osteoarthritis (OA) pain among middle-aged and older adults. This study is evaluating the effect of an investigational medication for the treatment of pain and improvement of function in adults with osteoarthritis of the knee. This topic was selected because of the high burden of osteoarthritis in the Medicare beneficiary population, because knee replacement surgeries are among the most common surgical interventions provided to Medicare beneficiaries, and because new technologies This clinical practice guideline was prepared by the AAOS Osteoarthritis of the Knee Guideline physician development group (clinical experts) with the assistance of the AAOS Clinical Quality and Value (CQV) Department (methodologists). Trial registration: ClinicalTrials. Oct 7, 2023 · Mesenchymal stem cells (MSCs) present a valuable treatment option for knee osteoarthritis with promising results. Furthermore, ongoing studies highlight the possibility of using growth factors like fibroblast growth factor 18 (FGF18) to promote cartilage regeneration. Our results showed that in vivo murine model of OA display a dose-dependent effect according to histological analysis. This study aimed to provide an overview of the clinical trials conducted on this subject. MOVE is a phase 2 clinical study for adults aged 45 to 80 who are living with knee osteoarthritis and obesity. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Oct 15, 2025 · Osteoarthritis clinical trials at UC Davis 3 research studies open to eligible people CNTX-6970 in Subjects With Knee Osteoarthritis Pain. Osteoarthritis (OA) is a common arthritic condition, affecting 10 million people in the UK alone. To develop recommendations for the design, conduct, and repo … Clinical trials for Osteoarthritis, Knee AND Pain The European Union Clinical Trials Register allows you to search for protocol and results information on: interventional clinical trials that were approved in the European Union (EU)/European Economic Area (EEA) under the Clinical Trials Directive 2001/20/EC clinical trials conducted outside the EU/EEA that are linked to European paediatric We performed a meta-analysis of the efficacy and safety of stem cell therapy as a clinical treatment of knee osteoarthritis. Osteoarthritis of the Knee - Scottsdale AZ. Clinical efficacy of intra-articular mesenchymal stromal cells for the treatment of knee osteoarthritis: a double-blinded prospective randomized controlled clinical trial. PIKASO Clinical Trial PIKASO (P reventing I njured K nees from Osteo a rthritis S everity O utcomes) is a collaborative, double-blind, placebo-controlled, randomized clinical trial testing whether metformin can slow or prevent osteoarthritis progression in people with major knee injuries. We Aug 8, 2024 · The results of the clinical trial show methotrexate, a medication already used for autoimmune conditions, to be effective in relieving both the pain and stiffness caused by knee osteoarthritis which affects 5. Double-Blind, Double Dummy, Randomized Comparison Study to Evaluate the Efficacy and Safety of Valdecoxib 10 mg Once Daily and Naproxen 500 mg Twice Daily in Treating the Signs and Symptoms of Osteoarthritis of the Knee Nov 11, 2024 · A listing of 30 Osteoarthritis clinical trials actively recruiting volunteers for paid trials and research studies in various therapeutic areas. This condition can break down the slick cartilage that helps your knee joint move smoothly. This study aims to evaluate the efficacy of acupuncture for KOA patients and calculate the required information size (RIS) to determine whether further clinical studies are required. Jan 8, 2025 · Garza JR, Campbell RE, Tjoumakaris FP, et al. Jul 27, 2023 · The study is a multicenter trial conducted to compare the effectiveness of an injection of a corticosteroid control to mesenchymal stem cell (MSC) preparations from autologous bone marrow concentrate (BMAC), adipose derived stem cells in the form of Stromal Vascular Fraction (SVF), and third-party human mesenchymal stem cells manufactured from umbilical cord tissue (UCT) for the treatment of This randomized clinical trial reports no additional benefit of an intra-articular injection of methylprednisolone before exercise among patients with osteoarthritis (OA) of the knee. This review began with a search of Pubmed using terms of OA, knee, and imaging. Currently, cell-based therapy is being explored to address the repair of damaged articular cartilage in the knee joint. The purpose of the present study was to systematically review the clinical and functional outcomes following mesenchymal stem cell application focusing on early to moderate knee osteoarthritis. Feb 16, 2024 · This is the first dose escalation clinical study that evaluated the therapeutic efficacy of UC-derived MSC (Cellistem) for moderate and symptomatic knee OA. Jul 1, 2025 · Conclusions and relevance: The results of this randomized clinical trial show that, compared to placebo, low-dose methotrexate did not reduce pain or effusion-synovitis over 52 weeks in patients with knee OA and effusion-synovitis. Participation in the study will last about 74 weeks. 89 Knee Osteoarthritis Trials Near You Power is an online platform that helps thousands of Knee Osteoarthritis patients discover FDA-reviewed trials every day. Radiographic methods are applied to assess cartilage degeneration and skeletal changes using the semi-quantitative Kellgren-Lawrence score, Ahlbäck classification, and Knee Osteoarthritis Grading System [40]. gov ID NCT04864392 Sponsor Novartis Pharmaceuticals Information provided by Novartis (Novartis Pharmaceuticals) (Responsible Party) What is the ACTiVION-I clinical trial? The ACTiVION-I study is an osteoarthritis (OA) clinical trial for adults over 40 years of age who have been diagnosed with OA in at least one knee. Nov 2, 2025 · The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. The success of Phase 2 has led to the TRIUMPH Phase 3 program, a comprehensive evaluation across five clinical trials examining retatrutide's effects on obesity, type 2 diabetes, cardiovascular disease, obstructive sleep apnea, and knee osteoarthritis. Evans and his team gave the experimental gene therapy to nine patients with osteoarthritis, delivering it directly into the knee joint. Osteoarthritis of the Knee and Clinical Trials Arthritis can be a painful, and debilitating condition to live with. Reducing pain remains the primary goal of osteoarthritis management, enhancing patient function and quality of life. Nov 6, 2025 · The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. Conducted at four sites with 480 diverse participants with varying levels of OA severity, the Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) study compared results from MSCs derived from Jun 2, 2025 · This randomized clinical trial investigates whether methotrexate has symptom-relieving and disease-modifying effects for participants with inflammatory knee osteoarthritis and effusion-synovitis. 6 days ago · SPRI and Neuromuscular Dynamics Launch NIH-Funded Clinical Trial to Advance Non-Surgical Knee Osteoarthritis Treatment byTim Allen November 18, 2025 Knee osteoarthritis (KOA) is a common chronic articular disease worldwide. It occurs when the protective cartilage in the knee joint wears down over time, leading to friction between bones and discomfort. Two-word combinations of two sets of key words “cartilage”; “joint”; BACKGROUND Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. Methods: An initial review of the COMET database of core outcome sets (COS) was undertaken to identify all domains reported in previous COS including individuals with hip and/or knee OA. By Methods: A randomized, double-blind, placebo-controlled trial was conducted. Massage may offer a safe and effective complement to the management of knee osteoarthritis. With the gradual increase in life expectancy and ageing population, KOA not Apr 12, 2023 · OHSU clinical trial validates this week’s FDA approval of implantable shock absorber; marks first new surgical treatment in decades for osteoarthritis of the knee. ClinicalConnection helps connect participants with clinical trials in their area. And with multiple forms affecting different parts of the body, there is still so much to learn about it and how to effectively treat it. Every trial we feature meets safety and ethical standards, giving patients an easy way to discover promising new treatments in the research stage. Clinical Trial: Osteoarthritis of knee About Clinical Trials Clinical research studies help to determine whether potential new medications (known as “investigational medications”) are safe and how well they work. These patients randomly received either active moxibustion (n = 55) or sham 14 hours ago · Nes-Ziona, Israel, Nov. The purpose of this study is to determine the safety and feasibility of autologous, adipose derived stromal vascular fraction injections in the treatment of knee osteoarthritis. This study was a narrative review of clinical trials identified from clinical trials databases to identify Phase II and III studies with a primary completion on or after The Osteoarthritis Initiative (OAI) is a nationwide multicenter, longitudinal, prospective observational study of knee osteoarthritis (OA). Find clinical trials for osteoarthritis today! Jul 30, 2025 · The purpose of this study is to investigate the safety and effectiveness of bone marrow aspirate concentrate (BMAC) in patients with moderate to severe osteoarthritis of the knee. May 1, 2015 · The Task Force of the Osteoarthritis Research Society published a set of recommendations on the design and conduct of clinical trials in patients with osteoarthritis (OA) in 1996 1. It is also the most common form of OA and is characterized by high morbidity and disability rates. The overall aim of the OAI Mar 26, 2024 · Imagine a day when joints could heal themselves. At MAC Clinical Research, we’re researching a potential new treatment that we hope can be the key to revolutionising knee OA care. Oct 30, 2024 · Weight reduction has been shown to alleviate symptoms of osteoarthritis of the knee, including pain. Feb 23, 2006 · Glucosamine and chondroitin sulfate alone or in combination did not reduce pain effectively in the overall group of patients with osteoarthritis of the knee. Information on the articular cartilage and subchondral bone responses to exercise may help to develop safe and feasible exercise programs which can potentially improve cartilage and bone properties. The effect of glucagon-like peptide-1 receptor agonists on outcomes in knee osteoarthritis among A Study of Comparing Functional Outcomes after Kinematic and Mechanical Alignment in Total Knee Arthroplasty Rochester, MN The study aim is to conduct a clinical research investigation to compare two alignment techniques used in contemporary total knee arthroplasty by means of a prospective non-randomized clinical trial. Although there are treatments available to manage symptoms, there is a need for ongoing research on knee osteoarthritis. gov Jul 25, 2018 · The initial findings of a Nature Medicine study describe a first-of-its-kind randomized clinical trial to identify the most effective source of cellular injections for knee arthritis. The Center for Osteoarthritis Research is a major center for research into the causes and treatment of osteoarthritis. A clinical trial is a carefully controlled study of the safety and effectiveness of a medical treatment, strategy, device, or other intervention for humans. Outcomes in-cluded the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC), patient and physician May 18, 2013 · This summary of the AAOS clinical practice guideline, “Treatment of Osteoarthritis of the Knee” contains a list of the evidence based treatment recommendations and includes only less invasive alternatives to knee replacement. Data were subset by location of OA (knee, hip), active agent Nov 29, 2022 · UCI Health and the UCI Alpha Clinic are conducting the first-in-human clinical trial of a stem cell-derived therapy to treat muscle atrophy associated with knee osteoarthritis. Clinical Trial: Osteoarthritis of the Knee NCT04440189 Title: Use of GID SVF-2 Device to Produce Autologous Adipose-Derived Stromal Vascular Fraction for Treatment of Osteoarthritis of the Knee: A Pivotal Medical Device Randomized Concurrent Controlled Study PI: J. The purpose of this study was to assess the quality of clinical trials published between 2010 and 2020 investigating intra-articular interventions in Mar 6, 2025 · Aim This double-blind, trial sought to assess the effectiveness of intra-articular ozone therapy at concentrations of 20 µg/mL and 40 µg/mL in managing pain and enhancing functional mobility in patients with knee osteoarthritis (KOA). The study will evaluate how well the investigational study therapy works as a potential treatment in decreasing Jun 24, 2014 · Introduction Our objective was to compare the effectiveness and safety of traditional Chinese moxibustion to that of sham moxibustion in patients with chronic knee osteoarthritis (KOA) pain. ( Nasdaq: ENLV, the 'Company”), a clinical-stage macrophage reprogramming immunotherapy company, today announced positive six-month efficacy data from the Phase IIa stage of its randomized, multi-country Phase I/II Allocetra™ trial (ENX-CL-05-001) in patients with moderate to severe knee osteoarthritis (OA). gov Identifier: NCT03815448. Jun 4, 2025 · Here, we tested the delivery of a gene therapeutic encoding the human IL-1Ra to the knee in a phase 1, open-label clinical trial that enrolled nine patients with radiographic knee OA. 5 days ago · In the MESKO clinical trial, treatment with low-dose methotrexate did not improve pain or joint inflammation in individuals with inflammatory knee osteoarthritis. [3,4] With FDA filing expected in late 2025 and potential approval in 2026, retatrutide could 53-Week Study Evaluating the Safety and Efficacy of Intra-articular Injections of TPX-100 With Mild to Severe Tibio-Femoral Osteoarthritis of the Knee 53-Week Study Evaluating the Safety and Efficacy of Intra-articular (IA) Injections of TPX-100 vs Placebo in Subjects with Mild to Severe Tibio-Femoral Osteoarthritis of the Knee 50 Years - 80 Years Mar 19, 2019 · Patients and methods Data from phase III placebo-controlled clinical trials of patients with moderate-to-severe OA of the knee or hip were pooled to evaluate tanezumab efficacy (four trials) and safety (nine trials). The goal of this document is to update the original OARSI recommendations specifically for the design, conduct, and reporting of clinical trials that target symptom or structure modification among individuals with knee osteoarthritis (OA). Methods Confirmatory Study of NeoCart in Knee Cartilage Repair Rochester, MN This confirmatory study is a prospective randomized trial comparing the efficacy and safety of an autologous chondrocyte tissue implant (NeoCart) to the surgical intervention microfracture in the treatment of cartilage defects in the knee. Peter Rubin, MD Osteoarthritis Clinical Trials Osteoarthritis is the most common type of arthritis and a very important cause of disability; therefore, clinical trials are often carried out to discover a way to cure it, and to test out new treatments meant to improve the quality of life of those who suffer from it. The population of this study was OA patients Jul 30, 2024 · The results of the clinical trial show methotrexate, a medication already used for autoimmune conditions, to be effective in relieving both the pain and stiffness caused by knee osteoarthritis which affects 5. Nov 2, 2023 · The multicenter phase 3 trial of stem cell therapy for osteoarthritis (MILES) for knee pain revealed that cell therapies showed no significant difference in knee pain outcomes, compared to Jan 18, 2023 · We are seeking participants for a new osteoarthritis of the knee clinical research study. Aug 12, 2023 · Painful knee osteoarthritis (KOA) is common, pharmacological treatment, however, is often hampered by limited tolerability. Nov 22, 2024 · The first patient treatment of Phase 3 clinical trial in Japan began in 2023 and was conducted at 13 medical centers, enrolling 130 patients with moderate to severe knee osteoarthritis (Kellgren & Lawrence Grade 2–3). IL-1Ra licensed for use in a clinical setting for the treatment of OA. Feb 2, 2023 · Cleveland Clinic researchers are leading three clinical trials investigating injectable biologic therapies for hip and knee osteoarthritis, including birth tissue particulate, bone marrow aspirate concentrate and platelet-rich plasma. Methods. Methods We performed a comprehensive search of PubMed, Embase, OVID, Cochrane Library and Web of Science databases from their inception to December 10th, 2023, identifying randomized controlled trials (RCTs) examining the effects of therapeutic options on Jul 28, 2025 · Mayo Clinic has since established a new process for accelerating clinical trial activation that could help researchers launch studies more quickly. These Jan 6, 2021 · Exercise is an essential component of the management of knee osteoarthritis. The purpose of this study is to investigate the correlation between a patient’s complete blood count with differential (CBC w/diff), platelet count, platelet-rich plasma (PRP) blood and platelet counts with a patient’s clinical outcome from a PRP injection for the treatment of knee osteoarthritis (OA). Credit: Pormezz / Shutterstock. Mar 14, 2025 · A clinical trial for MAG200, a stem cell-based therapy, demonstrated a significant 58% improvement in pain levels over 12 months among patients with knee osteoarthritis. Apr 15, 2025 · A new experimental growth factor therapy, however, appears to prevent a worsening of osteoarthritis by increasing the thickness of cartilage in the knee joint and preventing further loss, according to results from an early clinical trial that were published today in the Journal of the American Medical Association. Background: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Aug 1, 2019 · Objective. One of the most common forms of arthritis is osteoarthritis, a degenerative joint disease. Some cookies may process health information. In the recent study, Dr. Apr 1, 2024 · Treatment efficacy was assessed using changes in VAS pain score, Mean Western Ontario & McMaster Universities osteoarthritis (WOMAC) function score (normalized to 100; score ranging from 0 to100) and outcome measures in rheumatoid arthritis clinical trials (OMERACT)-Osteoarthritis Research Society (OARSI) set of responder criteria. 1,2 Reported improvement after an intervention is usually acknowledged to be due, in part, to the placebo effect. This Initiative is a public-private partnership between the National Institutes of Health (NIH) and private industry that seeks to improve diagnosis and monitoring of osteoarthritis (OA) and foster development of new treatments. Feb 21, 2025 · The goal of this clinical study is to learn if Hydrogel OA 2% injection is safe and whether it works to improve symptoms of diagnosed knee osteoarthritis in adults when compared to Hyaluronic Acid (Durolane), a treatment that is currently often used for treatment of knee osteoarthritis. Oct 23, 2024 · A promising result The Leeds clinical trial found that methotrexate, a medication used for autoimmune conditions, is also effective at relieving the pain and stiffness of knee osteoarthritis. This study was conducted in 2018–2019 on 80 patients over 18 years of age with diagnosed knee osteoarthritis and chronic knee pain. GP130: protector or mutineer? GP130 in particular recruits white blood cells to launch the offensive against infection. Feb 29, 2024 · Abstract Background: Based in part on the results of randomized controlled trials (RCTs) that suggest a beneficial effect over alternative treatment options, the use of platelet-rich plasma (PRP) for the management of knee osteoarthritis (OA) is widespread and increasing. A task force for the EULAR Standing Committee for Clinical Trials met in 1998 to determine the methodological and logistical approach required for the development of evidence based guidelines for treatment of knee OA. North Georgia Clinical Research has clinical trials dedicated to osteoarthritis of the knee. bqow qkel szci ieuijnwg vmlygzs uqwo bru zxmjemn ywayaac duiqzcp zaqdi crubgr telslcz medrh qvtzn